Radiologic-pathologic correlation. Cerebral toxoplasmosis and lymphoma in AIDS.

A 37-year-old human immunodeficiency virus (HIV)positive man had a 6-month history of progressive left-sided weakness and sensory loss. Additional symptoms included a 15.75-kg weight loss, fatigue, and anorexia. He had been HIV-seropositive for 21⁄2 years but had no previous acquired immunodeficiency syndrome (AIDS)-defining illnesses (Centers for Disease Control criteria, 1987). He had been on maintenance therapy with zidovudine and trimethoprim with sulfamethoxazole for approximately 1 year. On admission, he was febrile at 38.68C (101.58F). Physical examination showed a lethargic and cachectic male who was oriented only to his name and “hospital.” He had slow speech and comprehension with decreased attention but intact recent and remote memory. He also had left homonymous hemianopsia and left hemiparesis with increased tone and decreased bulk. Light touch, vibra-